The cut-off value for interleukin 34 as an additional potential inflammatory biomarker for the prediction of the risk of diabetic complications
The cut-off value for interleukin 34 as an additional potential inflammatory biomarker for the prediction of the risk of diabetic complications
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DOI：
10.3109/1354750x.2016.1138321
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发表时间：
2016-04-02
期刊：
影响因子：
2.6
通讯作者：
Waz, Piotr
中科院分区：
文献类型：
--
作者：
Zorena, Katarzyna;Jachimowicz-Duda, Olga;Waz, Piotr
在本研究中，我们决定评估血清白细胞介素 34 (IL-34) 水平是否对预测血管性糖尿病并发症的风险具有诊断价值。该研究包括 49 名 2 型糖尿病 (T2DM) 患者和 23 名高危人群。受试者工作特征（ROC）曲线分析表明，IL-34对于糖尿病并发症的风险比C反应蛋白（CRP）具有更强的辨别能力。 IL-34 的截止值确定为 91.2 pg/mL。我们研究的要点是确定 IL-34 作为预测血管糖尿病并发症风险的额外潜在炎症生物标志物。
In the present study, we have decided to evaluate whether serum interleukin 34 (IL-34) levels may have diagnostic value in predicting the risk of vascular diabetic complications. The study included 49 patients with type 2 diabetes mellitus (T2DM) and 23 high-risk group. The receiver operating characteristic (ROC) curve analysis has shown that IL-34 has more discriminatory power than C-reactive protein (CRP) for the risk of diabetic complications. The cut-off value for IL-34 was established as 91.2 pg/mL. The gist of our research was identification of IL-34 as an additional potential inflammatory biomarker for the prediction of the risk of vascular diabetic complications.