The pyogenic potential of the different Streptococcus anginosus group bacterial species: retrospective cohort study
The pyogenic potential of the different Streptococcus anginosus group bacterial species: retrospective cohort study
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DOI：
10.1017/s0950268817001807
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发表时间：
2017-10-01
影响因子：
4.2
通讯作者：
Paul, M.
中科院分区：
文献类型：
--
作者：
Kobo, O.;Nikola, S.;Paul, M.
咽峡炎链球菌群（SAG）细菌是化脓性感染（PI）的常见原因。我们通过一项2009年至2015年的回顾性、观察性、队列研究，检查了SAG物种与PI存在之间的相关性。在以色列的一家医院，对所有具有临床意义的SAG感染的成人进行了SAG菌种与PI（定义为脓肿、脓胸或深部/器官间隙手术部位感染）之间的相关性评估。PI的危险因素采用多因素后向逐步Logistic回归分析进行评估。我们确定了263例严重SAG感染的患者，其中182例（69%）由S。45例（17.1%）由星座链球菌引起，36例（13.7%）由中间链球菌引起。患者的平均年龄为56.8 ± 19.1岁。在160例（60%）患者中发现PI，大多数为非菌血症（147/160，91.8%），而大多数非PI患者为菌血症（70/103，68%）。S. anginosus和S.与S.中间肌的OR分别为0.18（95%CI 0.06-0.53）和0.14（0.04-0.48）。PI患者更年轻，一般而言，合并症较少。S.中间型与化脓性非菌血症感染有关，而S. anginosus和S.星座与菌血症有关，无脓肿或脓胸形成。这些数据可能表明这些SAG细菌的毒力机制的差异。
Streptococcus anginosus Group (SAG) bacteria are common causes of pyogenic infections (PIs). We examined the association between SAG species and the presence of a PI through a retrospective, observational, cohort study, between the years 2009 and 2015. All adults with clinically significant SAG infections in one hospital in Israel were assessed for association between SAG species and the presence of a PI defined as an abscess, empyema, or deep/organ space surgical site infection. Risk factors for PI were assessed using multivariate backward stepwise logistic regression analysis. We identified 263 patients with significant SAG infections, 182 (69%) of which were caused by S. anginosus, 45 (17.1%) by Streptococcus constellatus and 36 (13.7%) by Streptococcus intermedius. The mean age of the patients was 56.8 +/- 19.1 years. PIs were identified among 160 (60%) of the patients and were mostly non-bacteraemic (147/160, 91.8%), while most non-PI patients had bacteraemia (70/103, 68%). S. anginosus and S. constellatus were associated with a significantly lower incidence of PI than S. intermedius, OR 0.18 (95% CI 0.06-0.53) and 0.14 (0.04-0.48), respectively. Patients with PI were younger and, in general, had less co-morbidities. S. intermedius was associated with pyogenic non-bacteraemic infections, while S. anginosus and S. constellatus were associated with bacteraemia with no abscess or empyema formation. These data may indicate differences in virulence mechanisms of these SAG bacteria.