Tissue-specific implications of mitochondrial alterations in aging.
Tissue-specific implications of mitochondrial alterations in aging.
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DOI：
10.2741/e654
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Bai Y
中科院分区：
文献类型：
--
作者：
Liu D;Li H;Lu J;Bai Y
衰老是一个多因素的过程，在此过程中所有组织都会发生生理变化。线粒体功能下降在衰老过程和衰老相关疾病中发挥着重要作用。线粒体基因组编码属于氧化磷酸化系统的蛋白质复合物的13个必需亚基，而大多数线粒体相关基因由核基因组编码。细胞核和线粒体之间的协调对于线粒体生物发生和功能的调节至关重要。在这篇综述中，我们将讨论各种组织中与衰老相关的线粒体功能障碍及其对衰老相关疾病和衰老过程的影响。
Aging is a multifactorial process during which physiological alterations occur in all tissues. A decline in mitochondrial function plays an important role in the process of aging and in aging-associated diseases. The mitochondrial genome encodes 13 essential subunits of protein complexes belonging to the oxidative phosphorylation system, while most of the mitochondria-related genes are encoded by the nuclear genome. Coordination between the nucleus and mitochondria is crucial for the regulation of mitochondrial biogenesis and function. In this review, we will discuss aging-related mitochondrial dysfunction in various tissues and its implication in aging-related diseases and the aging process.