The whole prefrontal cortex is premotor cortex
The whole prefrontal cortex is premotor cortex
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DOI：
10.1098/rstb.2020.0524
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发表时间：
2022-02-14
影响因子：
6.3
通讯作者：
Hayden, Benjamin Y.
中科院分区：
文献类型：
--
作者：
Fine, Justin M.;Hayden, Benjamin Y.
我们认为，整个前额叶皮层（PFC）可以被看作是基本的运动前区的性质。通过这一点，我们的意思是PFC由一个行动抽象层次结构组成，其核心功能是在不同粒度级别上增强和减弱可能的行动计划。我们认为，层次结构的顶点应该围绕目标选择的过程，我们认为这是内在的一种形式的动作抽象的优化。解剖学和功能学证据支持这一观点，即这种层次结构起源于大脑的眶表面，并向背侧延伸到运动皮层。因此，我们的观点的位置眶额皮层在目标选择政策的优化中发挥着关键作用，并建议其其他建议的作用是这个更一般的功能的方面。我们提出的观点将重新构建悬而未决的问题，开辟新的研究领域，并将前额叶功能理论与进化原理相结合。这篇文章是主题“进化论透镜下的系统神经科学”的一部分。
We propose that the entirety of the prefrontal cortex (PFC) can be seen as fundamentally premotor in nature. By this, we mean that the PFC consists of an action abstraction hierarchy whose core function is the potentiation and depotentiation of possible action plans at different levels of granularity. We argue that the apex of the hierarchy should revolve around the process of goal-selection, which we posit is inherently a form of optimization over action abstraction. Anatomical and functional evidence supports the idea that this hierarchy originates on the orbital surface of the brain and extends dorsally to motor cortex. Accordingly, our viewpoint positions the orbitofrontal cortex in a key role in the optimization of goal-selection policies, and suggests that its other proposed roles are aspects of this more general function. Our proposed perspective will reframe outstanding questions, open up new areas of inquiry and align theories of prefrontal function with evolutionary principles. This article is part of the theme issue 'Systems neuroscience through the lens of evolutionary theory'.