Neuroimaging, cognition, light and circadian rhythms.
Neuroimaging, cognition, light and circadian rhythms.
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DOI：
10.3389/fnsys.2014.00126
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发表时间：
2014
影响因子：
3
通讯作者：
Vandewalle G
中科院分区：
文献类型：
--
作者：
Gaggioni G;Maquet P;Schmidt C;Dijk DJ;Vandewalle G
在人类中，睡眠和觉醒以及相关的认知过程通过睡眠稳态和昼夜节律系统之间的相互作用来调节。睡眠和昼夜节律的慢性中断在我们的社会中很常见，需要更好地了解调节睡眠，觉醒和相关认知过程的大脑机制。这篇综述总结了最近的调查，提供了第一个神经相关的睡眠稳态和昼夜节律对认知脑活动的综合影响。睡眠-觉醒调节中个体间差异的标志物，如睡眠和时钟基因的时间型和多态性，与皮层下和皮层区域对睡眠-觉醒周期操纵的认知脑反应变化相关。这篇综述还包括最近的数据，表明认知大脑活动受光的调节，这是认知和警觉性的强大调制器，也直接影响睡眠和昼夜节律。光照的影响随年龄、精神状态、PERIOD 3基因型以及睡眠稳态和昼夜节律时相的变化而变化。这些数据为人口统计学特征，睡眠-觉醒周期，昼夜节律和光线对大脑功能的贡献提供了新的见解。
In humans, sleep and wakefulness and the associated cognitive processes are regulated through interactions between sleep homeostasis and the circadian system. Chronic disruption of sleep and circadian rhythmicity is common in our society and there is a need for a better understanding of the brain mechanisms regulating sleep, wakefulness and associated cognitive processes. This review summarizes recent investigations which provide first neural correlates of the combined influence of sleep homeostasis and circadian rhythmicity on cognitive brain activity. Markers of interindividual variations in sleep-wake regulation, such as chronotype and polymorphisms in sleep and clock genes, are associated with changes in cognitive brain responses in subcortical and cortical areas in response to manipulations of the sleep-wake cycle. This review also includes recent data showing that cognitive brain activity is regulated by light, which is a powerful modulator of cognition and alertness and also directly impacts sleep and circadian rhythmicity. The effect of light varied with age, psychiatric status, PERIOD3 genotype and changes in sleep homeostasis and circadian phase. These data provide new insights into the contribution of demographic characteristics, the sleep-wake cycle, circadian rhythmicity and light to brain functioning.