Comparison of fat quantification methods: A phantom study at 3.0T
Comparison of fat quantification methods: A phantom study at 3.0T
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DOI：
10.1002/jmri.21201
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发表时间：
2008-01-01
影响因子：
4.4
通讯作者：
Langton, Christian M.
中科院分区：
文献类型：
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作者：
Bernard, Clare P.;Liney, Gary P.;Langton, Christian M.
目的：比较不同成像方法在3.0T条件下的单体素磁共振波谱（MRS）对体模脂肪含量的定量分析。材料和方法：采用GE Signa系统进行成像和波谱分析。构建了11个新型均质脂肪水体模，脂肪含量从0%到100%不等。这些使用三种技术成像，并与单体素非水抑制MRS。像素的脂肪分数的像素地图进行比较，并与MRS测定的测量值的平均值。结果：所有成像方法与MRS的相关性均显著（P < 0.001）：IDEAL（r（2）= 0.985）、IOP（r（2）= 0.888）、WS（r（2）= 0.939）、FS（r（2）= 0.938）。此外，IDEAL提供了脂肪分数的无伪影图，具有上级均匀性。在体内使用IDEAL的结果产生的值之间的9%至16%的相应的MRS value.Conclusion：这项工作表明，成像可以利用作为一个高分辨率的替代MRS的脂肪含量的定量。将来，我们打算在涉及脂肪测量的临床研究中用IDEAL代替MRS。
Purpose: To compare different imaging methods with single-voxel MR spectroscopy (MRS) for the quantification of fat content in phantoms at 3.0T.Materials and Methods: Imaging and spectroscopy was performed on a GE Signa system. Eleven novel homogeneous fat-water phantoms were constructed with variation in fat content from 0% to 100%. These were imaged using three techniques and compared with single-voxel non-water-suppressed MRS. Pixel-by-pixel maps of fat fraction were produced and mean values compared to MRS-deter mined measurements. Preliminary in vivo examinations were subsequently performed in the breast and spine to compare the best imaging technique with MRS.Results: All imaging methods significantly correlated with MRS (P < 0.001): IDEAL (r(2) = 0.985), IOP (r(2) = 0.888), WS (r(2) = 0.939), and FS (r(2) = 0.938). In addition, IDEAL provided artifact-free maps of fat fraction with superior uniformity. In vivo results using IDEAL produced values that were between 9% to 16% of the corresponding MRS values.Conclusion: This work demonstrates that imaging may be utilized as a high-resolution alternative to MRS for the quantification of fat content. In the future we intend to replace MRS with IDEAL in our clinical studies involving fat measurement.