Characteristics of positional nystagmus in patients with horizontal canal canalolithiasis or cupulopathy
Characteristics of positional nystagmus in patients with horizontal canal canalolithiasis or cupulopathy
复制标题
水平管管结石或杯形病患者位置性眼球震颤的特点
DOI：
10.1007/s00415-019-09435-5
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发表时间：
2019-10-01
影响因子：
6
通讯作者：
Shi, Haibo
中科院分区：
文献类型：
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作者：
Wang, Hui;Yao, Qingxiu;Shi, Haibo
目的位置性眼球震颤可能与多种疾病有关。本研究旨在比较水平小管结石患者的方向性水平位置性眼球震颤（DCPN）特征方法对52例患者的位置性眼球震颤的时间模式进行分析，比较3种类型的位置性眼球震颤的时间模式，并对3种类型的位置性眼球震颤的时间模式进行比较入选22例男性，30例女性，平均年龄49.6岁，均患有向地性或向远地性DCPN，根据眼球震颤特征将其分为HC-泪小管结石组、HC-Hcu组和HC-Lcu组。我们比较了它们的潜伏期、时间常数、峰值慢相速度（SPV）、达到峰值SPV强度的时间（Tpeak）和衰减到半峰强度的时间结果HC-Hcu组与HC-Hcu组SPV达峰时间无显著性差异（P> 0.05（23.1 ± 8.6 s）和HC-Lcu（24.4 ± 9.9 s）组（p= 0.733），但显著长于HC-胆管结石组（5.4 ± 3.5 s;p≤ 0.001）。泪小管结石组（36.4 ± 20.6º/s）、HC-Hcu组（30.1 ± 23.6º/s）和HC-Lcu组（21.4 ± 12.7º/s）的峰值强度无差异（p= 0.133）。三组间的潜伏期也无统计学差异（p= 0.200）。HC-Lcu组与HC-Hcu组在20 s、40 s、60 s、80 s的潜伏期、SPV峰值强度、Tpeak、T1/2 peak、SPV等方面的眼震特征相似。结论HC-Hcu组与HC-Lcu组的眼震特征相似，只是运动方向相反，提示HC-Hcu和HC-Lcu可能是由与潜在的泪小管结石不同的相似的病理生理机制（杯状病变）引起的。
ObjectivesPositional nystagmus can be related to various kinds of disorders. The current study aims to compare the direction-changing horizontal positional nystagmus (DCPN) characteristics in horizontal canal canalolithiasis (HC-canalolithiasis), heavy cupula of the horizontal canal (HC-Hcu), and light cupula of the horizontal canal (HC-Lcu), especially the temporal patterns of positional nystagmus in three disorders.Methods52 patients (22 males, 30 females; mean age, 49.6 years) presenting with geotropic or apogeotropic DCPN were enrolled, and they were divided into HC-canalolithiasis, HC-Hcu, or HC-Lcu groups according their nystagmus characteristics. We compared their latency, time constant, peak slow-phase velocity (SPV), time to reach peak SPV intensity (Tpeak), and time to decay to half-peak intensity (T1/2peak).ResultsThe time to reach peak SPV did not differ significantly between the HC-Hcu (23.1 ± 8.6 s) and HC-Lcu (24.4 ± 9.9 s) groups (p= 0.733), but was significantly longer than that of the HC-canalolithiasis group (5.4 ± 3.5 s;p≤ 0.001). The peak intensity did not differ among the canalolithiasis (36.4 ± 20.6º/s), HC-Hcu (30.1 ± 23.6º/s), and HC-Lcu (21.4 ± 12.7º/s) groups (p= 0.133). The onset latency also had no statistical difference among three groups (p= 0.200). The nystagmus patterns of HC-Lcu and HC-Hcu groups were similar, including latency, peak SPV intensity, Tpeak, T1/2peak, and SPV in 20 s, 40 s, 60 s, 80 s.ConclusionsThe nystagmus characteristics of HC-Hcu and HC-Lcu are similar, except for the fact that movement was in opposite directions, suggesting that HC-Hcu and HC-Lcu may result from a similar pathophysiological mechanism (cupulopathy) differing from that underlying canalolithiasis.