Stable Electroenzymatic Processes by Catalyst Separation
Stable Electroenzymatic Processes by Catalyst Separation
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DOI：
10.1002/chem.200900219
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发表时间：
2009-01-01
影响因子：
4.3
通讯作者：
Luetz, Stephan
中科院分区：
文献类型：
--
作者：
Hildebrand, Falk;Luetz, Stephan
劳动分工：近二十年来，电酶法合成手性醇中酶的快速失活一直是阻碍其应用的主要障碍。这种失活的原因现在已经阐明。水溶性聚合物介体的开发以及酶和介体的空间分离导致了第一个稳定的过程并显着提高了催化剂利用率（见图）。
Division of labour: The rapid enzyme inactivation in the electroenzymatic synthesis of chiral alcohols has been the main obstacle for synthetic applications during the last two decades. The reasons for this inactivation have now been elucidated. The development of a water‐soluble polymeric mediator and the spatial separation of enzyme and mediator led to the first stable process and significantly improved catalyst utilisations (see picture).