Regulatory mechanisms in cell-mediated immune responses. II. Comparison of culture-induced and alloantigen-induced suppressor cells in MLR and CML.
Regulatory mechanisms in cell-mediated immune responses. II. Comparison of culture-induced and alloantigen-induced suppressor cells in MLR and CML.
复制标题
细胞介导的免疫反应的调节机制。
DOI：
10.4049/jimmunol.118.5.1886
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发表时间：
1977
影响因子：
4.4
通讯作者：
R. J. Hodes
中科院分区：
文献类型：
--
作者：
Lee M. Nadler;R. J. Hodes
比较了两种抗原非特异性T细胞依赖性抑制系统对CML和MLR的影响。将脾细胞体外培养产生的抑制细胞与同种异体抗原体内引发产生的抑制细胞进行比较。培养诱导的抑制细胞本身不能在CML或MLR中反应;能够积极抑制未处理的反应细胞的CML和MLR反应;对丝裂霉素敏感;并且不产生容易证明的抑制上清液。同种抗原引发的细胞能够在CML和LR中响应;可以抑制MLR中的增殖，但仅在丝裂霉素处理后才能够抑制CML;并且产生抑制CML和MLR的抑制性上清液。除了对这些抑制基因群体之间的差异和相似性进行编目外，这些数据还被用来分析CML和MLR中抑制发生的机制。
Two antigen-nonspecific T cell-dependent suppressor systems were compared for their effects upon CML and MLR. Suppressor cells generated by an in vitro culture of spleen cells were compared with suppressor cells generated by in vivo priming with alloantigen. Culture-induced suppressor cells were themselves unable to respond in CML or MLR; were able to suppress actively the CML and MLR responses of untreated responding cells; were mitomycin-sensitive; and, produced no easily demonstrable suppressive supernatant. Alloantigen-primed cells were able to respond in CML and LR; could suppress proliferation in MLR, but were able to suppress CML only after mitomycin treatment; and, produced suppressive supernatants active in suppressing both CML and MLR. In addition to cataloging the differences and similarities between these suppressor populations, the data have been employed to analyze the mechanisms by which suppression occurs in CML and MLR.