Shiga toxin type 2 (Stx2), a potential agent of bioterrorism, has a short distribution and a long elimination half-life, and induces kidney and thymus lesions in rats
Shiga toxin type 2 (Stx2), a potential agent of bioterrorism, has a short distribution and a long elimination half-life, and induces kidney and thymus lesions in rats
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志贺毒素2型（Stx2）是一种潜在的生物恐怖主义因子，分布短，消除半衰期长，可引起大鼠肾脏和胸腺损伤
DOI：
10.1007/s00204-010-0639-0
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发表时间：
2011-09-01
影响因子：
6.1
通讯作者：
Wang, Hui
中科院分区：
文献类型：
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作者：
Liu, Yue-Nan;Wang, Sheng-han;Wang, Hui
志贺毒素2型是产志贺毒素的大肠杆菌产生的主要毒力因子，是一种潜在的生物恐怖毒素。在本研究中，用~(125)I作为指示剂来描述Stx2在体内的生物分布。大鼠静脉注射(Iv)。(125)I-Stx2按5.1-127.5微克/公斤体重三个剂量灌胃。Stx2在大鼠体内分布半衰期短(t(1/2)α，小于6min)，消除半衰期长。Stx2在大鼠体内的毒代动力学呈剂量依赖性和非线性。在注射后5min、0.5h和72h检测不同组织中Stx2的浓度。在肺、肾、鼻甲中发现了高放射性，有时在眼睛中也发现了高放射性，这在以前的研究中从未报道过。在初步评估中，在肾脏和胸腺发现了病变。
Shiga toxin type 2, a major virulence factor produced by the Shiga toxin-producing Escherichia coli, is a potential toxin agent of bioterrorism. In this study, iodine-125 ((125)I) was used as an indicator to describe the in vivo Stx2 biodistribution profile. The rats were injected intravenously (i.v.) with (125)I-Stx2 at three doses of 5.1-127.5 mu g/kg body weight. Stx2 had a short distribution half-life (t (1/2)alpha, less than 6 min) and a long elimination half-life in rat. The toxicokinetics of Stx2 in rats was dose dependent and nonlinear. Stx2 concentrations in various tissues were detected at 5-min, 0.5-h, and 72-h postinjection. High radioactivity was found in the lungs, kidneys, nasal turbinates, and sometimes in the eyes, which has never been reported in previous studies. In a preliminary assessment, lesions were found in the kidney and thymus.