Protection against cancer by probiotics: Relevant mechanism and in vivo and in vitro evidences between 2002 and 2010
Protection against cancer by probiotics: Relevant mechanism and in vivo and in vitro evidences between 2002 and 2010
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益生菌预防癌症：2002年至2010年的相关机制和体内外证据
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
JIAN SHENG WANG
中科院分区：
文献类型：
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作者：
SUNA ZHOU;MINGXIN ZHANG;JIAN SHENG WANG
益生菌已被用作IBD抗炎药物的替代品。目前，益生菌的抗癌作用越来越受到科学家的关注。已经提出了它们的抗癌作用的各种机制，特别是在体外实验中。在化学致癌物或皮下移植癌细胞诱导的动物模型中，研究了其相关机制，如调节免疫以提高抗肿瘤免疫功能，改变局部代谢产物以影响细胞增殖和凋亡，调节有害酶活性以发挥保护作用等。将益生菌应用于动物模型将有助于我们更好地了解其抗癌作用的潜在机制。这些动物实验结果为临床试验提供了理论依据，而在人体上的广泛研究为益生菌在癌症治疗中的临床应用提供了令人信服的基础。本文将对2002 - 2010年益生菌抗癌作用的细胞、动物模型和人体研究进行综述。
Probiotics have been used as alternatives for anti-inflammatory drugs in IBD. Now, more and more scientists are paying increasing attention on probiotics with the effects of anti-carcinogenic. Various mechanisms for their anticancer action have been suggested, particularly in vitro experiment. The involved mechanisms were studied in animal models induced by chemical carcinogen or subcutaneously implanted cancer cell line, such as modulating immune to improve anti-tumor immunological function, altering localmetabolic product to affect cell proliferation and apoptosis, regulating harmful enzyme activity to exert a protective effect and so on.As we know, in vivo animal models are designed to mimic the process of carcinogenesis in human, and administrating probiotics to animal models will help us to better understand the underlyingmechanisms of the anticancer effect. These animal evidences provide theory basis for clinical trial, and the extensive studies on human provide a convincing base for clinical application of probiotics in cancer treatment. This studywill reviewevidences of cellular, animal model and human study on anticancer effect of probiotics between 2002 and 2010.