Relations of Blood Inflammatory Marker Levels With Cerebral Microbleeds
Relations of Blood Inflammatory Marker Levels With Cerebral Microbleeds
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DOI：
10.1161/strokeaha.111.621193
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发表时间：
2011-11-01
期刊：
影响因子：
8.3
通讯作者：
Kitagawa, Kazuo
中科院分区：
文献类型：
--
作者：
Miwa, Kaori;Tanaka, Makiko;Kitagawa, Kazuo
背景和目的-脑微出血（CMB）见于老年人，被认为是小血管疾病的表现之一。虽然炎症过程不仅在大动脉疾病中引起了广泛关注，而且在小血管疾病中也引起了广泛关注，但它们在CMB中的参与仍有待确定。本研究的目的是阐明炎症标志物水平和CMB之间的关系。方法431例无脑血管病史的患者前瞻性入选。通过梯度回波磁共振成像评估CMB的存在和数量。作为常见的炎症标志物，血清超敏C反应蛋白（hsCRP），白细胞介素-6（IL-6），白细胞介素-18（IL-18）的水平进行了评估。在35例患者中，至少有一个CMB发现在深部，但30例患者有严格的叶CMB。hsCRP、IL-6和IL-18水平在伴有CMB的患者中高于不伴有CMB的患者。Logistic回归分析显示，在调整年龄和性别后，以及在额外调整心血管危险因素、无症状腔隙性脑梗死和白色高信号后，每种炎症标志物水平的每1 SD增加与CMB的存在显著相关。hsCRP、IL-6和IL-18的OR（95%CI）分别为1.81（1.35-2.46）、1.73（1.18-2.61）和2.41（1.44-4.52）。此外，炎症标志物水平与深和肺叶CMB。结论高水平的hsCRP，IL-6和IL-18与CMB，在深和肺叶的位置，这表明在CMB的炎症的参与。（中风。2011;42：3202-3206.）
Background and Purpose-Cerebral microbleeds (CMB) are observed in the elderly and have been regarded as one of the manifestations of small vessel disease. Although inflammatory processes have attracted much attention not only in large-artery disease, but also in small vessel disease, their involvement in CMB remains to be determined. The purpose of this study is to clarify relations between inflammatory marker levels and CMB.Methods-Four hundred thirty-one patients without histories of cerebrovascular diseases were prospectively enrolled. The presence and number of CMB were assessed on gradient-echo magnetic resonance imaging. As common inflammatory markers, serum levels of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and interleukin-18 (IL-18) were evaluated.Results-CMB were found in 65 patients (15%). In 35 patients, at least one CMB was found in deep locations, but 30 patients had strictly lobar CMB. Levels of hsCRP, IL-6, and IL-18 were higher in patients with CMB than in those without. Logistic regression analyses showed that each 1SD increase in each inflammatory marker level was significantly associated with the presence of CMB after adjustment for age and sex, and after additional adjustment for cardiovascular risk factors, silent lacunar infarction, and white matter hyperintensity. The OR (95% CI) of hsCRP, IL-6, and IL-18 was 1.81 (1.35-2.46), 1.73 (1.18-2.61), and 2.41 (1.44-4.52), respectively. Furthermore, the inflammatory marker levels were associated with both deep and lobar CMB.Conclusions-Higher levels of hsCRP, IL-6, and IL-18 are associated with CMB, in both deep and lobar locations, suggesting the involvement of inflammation in CMB. (Stroke. 2011;42:3202-3206.)