EFFECT OF ALCOHOL ON URINARY AND BLOOD DOLICHOLS
EFFECT OF ALCOHOL ON URINARY AND BLOOD DOLICHOLS
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DOI：
10.1139/o92-062
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发表时间：
1992-06-01
期刊：
影响因子：
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通讯作者：
SALASPURO, M
中科院分区：
文献类型：
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作者：
ROINE, R;NYKANEN, I;SALASPURO, M
Alcohol appears to affect dolichol metabolism, as both serum and urinary dolichol concentrations were found to be significantly higher in alcoholics than in social drinkers. Furthermore, acute heavy drinking (5.5 g alcohol/kg body weight during 42 h) increased urinary dolichol excretion significantly, whereas moderate drinking (60 g/day for 10 days) had no effect. Increased urinary dolichol concentrations in alcoholics returned rapidly to normal with a half-life decay of 3 days, whereas increased serum dolichol concentrations did not change during a 7-day observation period. The mechanism behind alcohol-induced alterations in dolichol metabolism remains unclear, but based on our results, it seems likely that serum and urinary dolichols are regulated independently from each other.
