Promoter architecture and the evolvability of gene expression.
Promoter architecture and the evolvability of gene expression.
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DOI：
10.1186/jbiol204
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发表时间：
2009
影响因子：
--
通讯作者：
Verstrepen KJ
中科院分区：
文献类型：
--
作者：
Tirosh I;Barkai N;Verstrepen KJ
基因表达的进化变化是表型进化的主要驱动力。在酵母中，表达迅速分化的基因与特定的启动子特征相关，包括TATA盒、核小体覆盖的启动子和串联重复的不稳定区的存在。在这里，我们讨论如何这些启动子特性可能赋予一个固有的表达能力的灵活性。
Evolutionary changes in gene expression are a main driver of phenotypic evolution. In yeast, genes that have rapidly diverged in expression are associated with particular promoter features, including the presence of a TATA box, a nucleosome-covered promoter and unstable tracts of tandem repeats. Here, we discuss how these promoter properties may confer an inherent capacity for flexibility of expression.