Quinoxaline-2,3-diones: potential D-amino acid oxidase (DAAO) inhibitors
Quinoxaline-2,3-diones: potential D-amino acid oxidase (DAAO) inhibitors
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DOI：
10.1007/s00044-014-1068-z
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发表时间：
2014-11-01
影响因子：
2.6
通讯作者：
Wang, Yongxiang
中科院分区：
文献类型：
--
作者：
Xie, Dongsheng;Wang, Yanchao;Wang, Yongxiang
制备了一系列喹喔啉-2，3-二酮化合物，并对其体外D-氨基酸氧化酶（DAAO）抑制活性进行了评价，IC 50值范围为0.6 - 15 μ M。SAR分析揭示了它们与DAAO的结合模式，为进一步设计新型高效DAAO抑制剂提供了重要线索。
A family of quinoxaline-2,3-diones was prepared and evaluated to exhibit D-amino acid oxidase (DAAO) inhibitory activities with IC50 values ranging from 0.6 to 15 mu M in vitro. SAR analysis revealed their binding modes with DAAO and provided an important clue for further design of highly potent DAAO inhibitors with novel structures.