ACTINOPLANONES-A AND ACTINOPLANONES-B, NEW CYTO-TOXIC POLYCYCLIC XANTHONES FROM ACTINOPLANES SP
ACTINOPLANONES-A AND ACTINOPLANONES-B, NEW CYTO-TOXIC POLYCYCLIC XANTHONES FROM ACTINOPLANES SP
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DOI：
10.7164/antibiotics.41.502
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发表时间：
1988-04-01
影响因子：
3.3
通讯作者：
KODAMA, M
中科院分区：
文献类型：
--
作者：
KOBAYASHI, K;NISHINO, C;KODAMA, M
从游动放线菌（Actinoplanes sp. R-304）的培养液中分离得到两个新的多环口山酮类化合物：游动放线菌酮A（1）和B（2）。化合物1对HeLa细胞具有极强的细胞毒性（IC 50 0.00004 μ g/ml）。化合物1和2的结构主要是通过2D异序相关NMR实验分析确定的。通过圆二色性光谱和NMR分析，使用手性衍生物（α-β-环己基的酯），化合物的不对称碳的绝对构型被指定为9 R、24 S、25 R和27 S。甲氧基-α-（三氟甲基）乙酸）。
Two new cytotoxic polycyclic xanthones, actinoplanones A (1) and B (2) were isolated from the culture broth of Actinoplanes sp. R-304 by monitoring their bioactivity against HeLa cells. Compound 1 was extremely cytotoxic (IC50 0.00004 .mu.g/ml) against HeLa cells. The structures of 1 and 2 were established mainly by analyses of 2D heteronuclear correlation NMR experiments. The absolute configurations of the asymmetric carbons of the compounds have been assigned to be 9R, 24S, 25R and 27S by circular dichroism spectra and NMR analysing using chiral derivatives (esters of .alpha.-methoxy-.alpha.-(trifluoromethyl)acetic acid).