Falls and functional impairments in cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN): a University of Rochester CCOP study
Falls and functional impairments in cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN): a University of Rochester CCOP study
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DOI：
10.1007/s00520-013-1766-y
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发表时间：
2013-07-01
影响因子：
3.1
通讯作者：
Mohile, S. G.
中科院分区：
文献类型：
--
作者：
Gewandter, J. S.;Fan, L.;Mohile, S. G.
本研究旨在描述癌症幸存者中福尔斯和功能障碍（FI）的患病率及其与化疗诱导的周围神经病变（CIPN）的相关性，我们分析了自报CIPN评分> 4/10的癌症幸存者的III期RCT基线评估。患者完成了EORTC QLQ-CIPN-20神经病变评估，并报告了前3个月内的福尔斯。使用弱势老年人量表的日常生活活动子部分定义FI。使用逻辑回归分析了基线特征和CIPN与福尔斯和FI的关系。在421名患者中，11.9%的患者最近经历过福尔斯，26.6%的患者报告了FI。运动神经病变是与福尔斯相关的唯一因素（OR = 1.127，p = 0.01）。与FI相关的因素包括非白色种族（相对于非白色，OR = 0.335白色，0.781，p = 0.01）和运动神经病变评分较高（OR = 1.262，p < 0.0001）。CIPN，主要是运动性的，与福尔斯和FI相关。未来的前瞻性研究应该调查运动神经病变严重程度预测福尔斯的能力。
This study was conducted in order to characterize the prevalence of falls and functional impairments (FIs) and their association with chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors.We analyzed baseline assessments from a phase III RCT in cancer survivors with self-reported CIPN scores of > 4 out of 10. Patients completed the EORTC QLQ-CIPN-20 for neuropathy and reported falls in the previous 3 months. FIs were defined using the Activities of Daily Living subsection of the Vulnerable Elder's Scale. Associations of baseline characteristics and CIPN with falls and FIs were examined using logistic regression.Of 421 patients, 11.9 % experienced recent falls and 26.6 % reported FIs. Motor neuropathy was the only factor associated with falls (OR = 1.127, p = 0.01). Factors associated with FIs included non-white race (OR = 0.335 white relative to non-white, 0.781, p = 0.01) and greater motor neuropathy scores (OR = 1.262, p < 0.0001).CIPN, primarily motor, is associated with falls and FIs. Future prospective research should investigate the ability of motor neuropathy severity to predict falls.