ACUTE EFFECTS OF PM-10 POLLUTION ON PULMONARY-FUNCTION OF SMOKERS WITH MILD-TO-MODERATE CHRONIC OBSTRUCTIVE PULMONARY-DISEASE
ACUTE EFFECTS OF PM-10 POLLUTION ON PULMONARY-FUNCTION OF SMOKERS WITH MILD-TO-MODERATE CHRONIC OBSTRUCTIVE PULMONARY-DISEASE
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DOI：
10.1164/ajrccm/147.6_pt_1.1336
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发表时间：
1993-06-01
期刊：
影响因子：
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通讯作者：
KANNER, RE
中科院分区：
文献类型：
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作者：
POPE, CA;KANNER, RE
这项研究评估了可吸入颗粒物空气污染(PM10)与轻度到中度气流受限吸烟者肺功能(FEV1、FEV1/FVC和FVC)变化的关系。盐湖城肺健康研究参与者的肺活量数据是在初次筛查后相隔10至90天的两次筛查中使用的，其中包括肺活量测定。我们分析了两次肺活量检查期间参与者肺功能(DELTAFEV1、DELTAFEV1/FVC和DELTAFVC)的差异。肺功能的变化与PM10之间存在显著的相关性。DELTAFEV1和DELTAFEV1/FVC与PM10的变化呈负相关。虽然这些相关性很小，只能解释DELTAFEV1中约2%至3%的变异，但它们始终是负的，在统计学上具有显著意义(p小于或等于0.01)。平均而言，PM10每增加100微克/立方米，FEV1的边际降幅约为2%。DELTAFVC和PM10之间的相关性一直是负的，但它们在统计学上没有显著意义。未观察到DELTAFEV1、DELTAFEV1/FVC或DELTAFVC与每日温度变化之间的一致性或统计学意义上的相关性。PM10对男性的影响大于对女性的影响。根据乙酰甲胆碱吸入激发试验，有非特异性呼吸道高反应性(AHR)的患者与没有AHR的患者的效果几乎相同。我们得出结论，在目前的吸烟者中，PM10可能对肺功能有微小的一过性负面影响，而这种影响并不完全被他们的吸烟习惯所掩盖。
This study assessed the association between respirable particulate air pollution (PM10) and changes in the pulmonary function (FEV1, FEV1/FVC, and FVC) of smokers with mild to moderate airflow limitation. Spirometric data of Salt Lake City participants in The Lung Health Study were used from two screening visits 10 to 90 days apart after an initial screening visit, which included spirometry. We analyzed differences in pulmonary function (DELTAFEV1, DELTAFEV1/FVC, and DELTAFVC) for participants between the two spirometry visits. Significant associations between changes in pulmonary function and PM10 were observed. DELTAFEV1 and DELTAFEV1/FVC were inversely associated with changes in PM10. Although these associations were small, explaining only about 2 to 3% of the variance in DELTAFEV1, they were consistently negative and statistically significant (p less-than-or-equal-to 0.01). On average, an increase in PM10 equal to 100 mug/m3 was associated with a marginal decline in FEV1 equal to approximately 2%. Associations between DELTAFVC and PM10 were consistently negative, but they were not statistically significant. No consistent or statistically significant associations between DELTAFEV1, DELTAFEV1/FVC, or DELTAFVC with changes in daily temperatures were observed. The effect of PM10 was greater for men than for women. The effect was nearly the same for those with nonspecific airway hyperresponsiveness (AHR), based on methacholine inhalation challenge testing, versus those without AHR. We conclude that in current smokers PM10 possibly has a small transient negative effect on lung function that is not entirely obscured by their smoking habit.