Clinical significance of serum S100A12 in acute otitis media in young children.
Clinical significance of serum S100A12 in acute otitis media in young children.
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DOI：
10.1097/inf.0b013e31824672cb
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Pichichero ME
中科院分区：
文献类型：
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作者：
Liu K;Pichichero ME
S100 A12是一种钙结合蛋白，主要在中性粒细胞中表达，以响应感染或炎症。急性中耳炎（AOM）是一种主要由肺炎链球菌（Spn）、无法分型的流感嗜血杆菌（NTHi）和/或卡他莫拉菌（Mcat）引起的局部感染。为了研究S100 A12值是否可以作为诊断标志物，在AOM发病前、发病时和恢复后检测了幼儿的血清S100 A12浓度。在116名AOM患儿中，我们发现，与感染前相比，AOM发作时血清S100 A12浓度显著升高（p=0.0001），并在患儿从感染中恢复时恢复至正常水平（p=0.01）。S100 A12的升高与中耳中Spn（p=0.004）或NTHi（p=0.04）的存在相关，但与Mcat或上呼吸道病毒感染无关。血清S100 A12值的变化与AOM的发生频率及患儿年龄无关。S100 A12可能是一个有用的生物标志物的发病AOM由于SPN和NTHi，并为以下儿童AOM。
S100A12 is a calcium-binding protein predominantly expressed in neutrophil granulocytes in response to infections or inflammation. Acute otitis media (AOM) is a local infection mainly caused by Streptococcus pneumoniae (Spn), nontypeable Haemophilus influenzae (NTHi) and/or Moraxella catarrhalis (Mcat). To study if S100A12 values could serve as a diagnostic marker, serum S100A12 concentrations were tested in young children before, at onset and after recovery from AOM. Among 116 children with AOM we found that serum S100A12 concentrations were significantly increased at onset of AOM compared to before infection (p=0.0001), and returned to normal levels when the children recovered from the infection (p=0.01). Elevation of S100A12 correlated with the presence of Spn (p=0.004) or NTHi (p=0.04) in the middle ear, but not with Mcat or upper respiratory viral infection. Change in serum value of S100A12 at onset of AOM were not related to the frequency of occurrence of AOM or the age of the child. S100A12 may be a useful biomarker for onset of AOM due to Spn and NTHi; and for following children with AOM.