Association of the polymorphisms in the gene encoding thyroglobulin with the development and prognosis of autoimmune thyroid disease
Association of the polymorphisms in the gene encoding thyroglobulin with the development and prognosis of autoimmune thyroid disease
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DOI：
10.1080/08916934.2017.1344971
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发表时间：
2017-01-01
期刊：
影响因子：
3.5
通讯作者：
Iwatani, Yoshinori
中科院分区：
文献类型：
--
作者：
Mizuma, Tomoyo;Watanabe, Mikio;Iwatani, Yoshinori
Graves病（GD）和桥本病（HD）均为自身免疫性甲状腺疾病（AITDs），其预后各不相同。我们研究了甲状腺球蛋白（TG）基因多态性与AITD发病机制的关系。我们对137HD患者、131名GD患者和89名健康对照者的TG rs180195G/A、rs853326G/A、rs2076740C/T、rs2703013G/T、rs2958692C/T和rs733735A/G多态性进行基因分型，并检测TG mRNA表达水平和血清TG水平。TG rs180195 GG基因型在HD患者中更为常见（p= 0.0277）， GG基因型患者CD4（+）细胞中高水平TG mRNA的比例高于A携带者（p= 0.0107）。TG rs2703013 TT基因型在AITD中较少出现（p= 0.0186）， TT基因型个体的血清TG水平低于G携带者（p= 0.0170）。在TG rs2958692多态性中，T等位基因在难治性GD中比在缓解性GD中更常见（p= 0.0055）， TT基因型GD患者的血清抗甲状腺球蛋白抗体（TgAb）滴度低于C携带者（p= 0.0151）。在TG rs2076740多态性中，T携带者HD患者血清TgAb滴度高于CC基因型患者（p= 0.0359）。TG基因的snp与HD和GD的发展、GD的难固性、TG mRNA表达水平、血清TG和血清TgAb有关。
Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid diseases (AITDs), and the prognosis of AITDs is different for each patient. We examined the association of polymorphisms in the Thyroglobulin (TG) gene with the pathogenesis of AITD. We genotyped TG rs180195G/A, rs853326G/A, rs2076740C/T, rs2703013G/T, rs2958692C/T and rs733735A/G polymorphisms in 137HD patients, 131 GD patients and 89 healthy controls and also examined the levels of TG mRNA expression and serum TG. The TG rs180195 GG genotype was more frequent in HD patients (p=.0277), and the proportion of CD4(+) cells with high levels of TG mRNA was greater in individuals with the GG genotype than in A carriers (p=.0107). The TG rs2703013 TT genotype was less frequent in AITD (p=.0186), and serum TG levels were lower in individuals with the TT genotype than in G carriers (p=.0170). In the TG rs2958692 polymorphism, the T allele was more frequent in intractable GD than in GD in remission (p=.0055), and serum titres of anti-thyroglobulin antibody (TgAb) were lower in GD patients with the TT genotype than in C carriers (p=.0151). In the TG rs2076740 polymorphism, serum titres of TgAb were higher in HD patients who were T carriers than in those with the CC genotype (p=.0359). SNPs in the TG gene were associated with the development of HD and GD, the intractability of GD, and the levels of TG mRNA expression, serum TG, and serum TgAb.