X-ray fluorescent CT imaging of cerebral uptake of stable-iodine perfusion agent iodoamphetamine analog IMP in mice
X-ray fluorescent CT imaging of cerebral uptake of stable-iodine perfusion agent iodoamphetamine analog IMP in mice
复制标题
DOI：
10.1107/s0909049508031853
复制
发表时间：
2009-01-01
影响因子：
2.5
通讯作者：
Akatsuka, Takao
中科院分区：
文献类型：
--
作者：
Takeda, Tohoru;Wu, Jin;Akatsuka, Takao
利用x射线荧光计算机断层扫描（XFCT），记录了一种稳定碘标记的脑灌注剂碘安非他明类似物（I-127-IMP）在小鼠大脑中的体内和体外分布。以0.5 mm平面内空间分辨率描绘皮层、海马和丘脑的活体脑灌注。在0.25 mm平面内空间分辨率的离体XFCT图像可以可视化这些区域的详细结构。海马的XFCT图像质量与I-125-IMP放射自显像相当。这些结果突出了XFCT的敏感性及其在不使用放射性药物的情况下评估小动物脑灌注的巨大潜力。
Using X-ray fluorescent computed tomography (XFCT), the in vivo and ex vivo cerebral distribution of a stable-iodine-labeled cerebral perfusion agent, iodoamphetamine analog (I-127-IMP), has been recorded in the brains of mice. In vivo cerebral perfusion in the cortex, hippocampus and thalamus was depicted at 0.5 mm in-plane spatial resolution. Ex vivo XFCT images at 0.25 mm in-plane spatial resolution allowed the visualisation of the detailed structures of these regions. The quality of the XFCT image of the hippocampus was comparable with the I-125-IMP autoradiogram. These results highlight the sensitivity of XFCT and its considerable potential to evaluate cerebral perfusion in small animals without using radioactive agents.