The Malaria-High Blood Pressure Hypothesis.
The Malaria-High Blood Pressure Hypothesis.
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DOI：
10.1161/circresaha.116.308763
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发表时间：
2016-06-24
影响因子：
20.1
通讯作者：
Scott JA
中科院分区：
文献类型：
--
作者：
Etyang AO;Smeeth L;Cruickshank JK;Scott JA
一些研究已经证明了传染病和心血管疾病之间的联系。疟疾和高血压在许多低收入和中等收入国家普遍存在，但它们之间可能存在的联系尚未得到考虑。在这篇文章中，我们概述了疟疾和高血压之间可能联系的基础，并讨论了如何证实或驳斥这一假设。我们回顾了有关高血压相关因素的已发表文献，并检查这些因素是否也与疟疾有关。然后我们考虑了各种可以用来检验假设的研究设计。疟疾导致低出生体重、营养不良和炎症，所有这些都与高收入国家的高血压有关。疟疾和高血压之间的假设联系可以通过使用生态、队列或孟德尔随机化研究来检验，每一项研究都提出了具体的挑战。确认高血压与疟疾之间存在致病联系将是预防和控制高血压工作的一个范式转变，并将刺激对传染病和非传染性疾病之间联系进行更广泛的研究。
Several studies have demonstrated links between infectious diseases and cardiovascular conditions. Malaria and hypertension are widespread in many low- and middle-income countries, but the possible link between them has not been considered. In this article, we outline the basis for a possible link between malaria and hypertension and discuss how the hypothesis could be confirmed or refuted. We reviewed published literature on factors associated with hypertension and checked whether any of these were also associated with malaria. We then considered various study designs that could be used to test the hypothesis. Malaria causes low birth weight, malnutrition, and inflammation, all of which are associated with hypertension in high-income countries. The hypothetical link between malaria and hypertension can be tested through the use of ecological, cohort, or Mendelian randomization studies, each of which poses specific challenges. Confirmation of the existence of a causative link with malaria would be a paradigm shift in efforts to prevent and control hypertension and would stimulate wider research on the links between infectious and noncommunicable disease.