Body mass index and mortality from cardiovascular disease among Japanese men and women - The JACC study
Body mass index and mortality from cardiovascular disease among Japanese men and women - The JACC study
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DOI：
10.1161/01.str.0000169925.57251.4e
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发表时间：
2005-07-01
期刊：
影响因子：
8.3
通讯作者：
Tamakoshi, A
中科院分区：
文献类型：
--
作者：
Cui, RZ;Iso, H;Tamakoshi, A
背景和目的 - 尽管超重在西方国家是心血管疾病的重要危险因素，但在日本，其患病率较低，超重的影响尚未得到很好的阐明。 方法 - 共有 104 928 名日本人（43 889 名男性和 61 039 名女性），年龄在 40 至 79 岁之间，入组时无中风、冠心病和癌症，参加了日本癌症风险评估协作队列研究由 Monbusho（JACC 研究）于 1988 年至 1990 年间进行。系统监测截至 1999 年底完成，随访了 1 042 835 人年，并根据国际疾病分类确定了根本死因。结果 - 总共有 765 例中风（191 例实质内出血）、379 例冠心病和 1707 例心血管疾病男士用；女性则分别为 685 人（145 人）、256 人、1432 人。与体重指数（BMI）23.0至24.9的人相比，BMI≥27.0 kg/m(2)的人患冠心病的风险较高；对于男性和女性，各自的多变量相对风险（95％CI）分别为2.05（1.35至3.13）和1.58（0.95至2.62）。 BMI<18.5 kg/m2的人发生总卒中和实质内出血的风险较高，男性和女性的多变量相对风险分别为总卒中1.29（1.01～1.49）和1.92（1.49～2.47），总卒中多变量相对风险为1.96（1.16～3.31）和2.32（1.36～1.49）。 3.97）用于脑实质内出血。当排除 5 年内的死亡或考虑吸烟状况时，这些超额风险并没有发生重大变化。 结论 - 对于日本男性和女性，高 BMI 与冠心病风险增加相关，而低 BMI 与实质内出血相关。
Background and Purpose - Although overweight is an important risk factor for cardiovascular disease in Western countries, the impact of overweight has not been well elucidated in Japan, where its prevalence is low.Methods - A total of 104 928 Japanese ( 43 889 men and 61 039 women) aged 40 to 79 years, free of stroke, coronary heart disease, and cancer at entry participated in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho ( JACC Study) between 1988 and 1990. Systematic surveillance was completed until the end of 1999, with 1 042 835 person years of follow-up, and the underlying causes of death were determined based on the International Classification of Diseases.Results - There were 765 total strokes ( 191 intraparenchymal hemorrhages), 379 coronary heart diseases, and 1707 total cardiovascular diseases for men; and for women, there were 685 ( 145), 256, and 1432, respectively. Compared with persons with body mass index (BMI) 23.0 to 24.9, those with BMI >= 27.0 kg/m(2) had a higher risk of coronary heart disease; for men and women, the respective multivariate relative risk ( 95% CI) was 2.05 ( 1.35 to 3.13) and 1.58 ( 0.95 to 2.62). Persons with BMI < 18.5 kg/m2 had higher risk of total stroke and intraparenchymal hemorrhage, for men and women, the respective multivariate relative risk was 1.29 ( 1.01 to 1.49) and 1.92 ( 1.49 to 2.47) for total stroke and 1.96 (1.16 to 3.31) and 2.32 (1.36 to 3.97) for intraparenchymal hemorrhage. These excess risks did not alter materially when deaths within 5 years were excluded or when smoking status was taken into account.Conclusions - For Japanese men and women, high BMI was associated with increased risk of coronary heart disease, whereas low BMI was associated with intraparenchymal hemorrhage.