Vascular adaptation to deconditioning and the effect of an exercise countermeasure: results of the Berlin Bed Rest study
Vascular adaptation to deconditioning and the effect of an exercise countermeasure: results of the Berlin Bed Rest study
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DOI：
10.1152/japplphysiol.00118.2005
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发表时间：
2005-10-01
影响因子：
3.3
通讯作者：
Hopman, MTE
中科院分区：
文献类型：
--
作者：
Bleeker, MWP;De Groot, PCE;Hopman, MTE
缺乏锻炼是心血管疾病的一个危险因素。血管对去适应的生理学尚未阐明。本研究的目的是评估卧床休息去适应化对腿部管道动脉血管尺寸和功能的影响。此外，还评估了抗振运动作为卧床期间血管失调对策的有效性。16名健康男性被随机分配到卧床休息（BR-Ctrl）或卧床休息与抗振运动（BR-RVE）。在严格水平卧床休息25天和52天之前和之后，通过回波多普勒超声测量动脉直径、血流、血流介导的扩张（FMD）和硝酸甘油介导的扩张。在BR对照组中，卧床休息25天后股总动脉直径下降13 +/- 3%，卧床休息52天后下降17 +/- 1%（P < 0.001）。在BR-RVE组中，直径的这种减小显著减弱（25天后为5 +/-2%，52天后为6 +/-2%，P < 0.01 vs. BR-Ctrl）。两组卧床休息后基线血流量均无变化。卧床休息52天后，两组的FMD和硝酸甘油介导的股浅动脉扩张均增加，可能是由于一氧化氮敏感性增加。总之，卧床不起伴随着导管动脉直径的减小和对一氧化氮的反应性增加。抗振训练能有效地减轻卧床后下肢动脉管径的减小。
Deconditioning is a risk factor for cardiovascular disease. The physiology of vascular adaptation to deconditioning has not been elucidated. The purpose of the present study was to assess the effects of bed rest deconditioning on vascular dimension and function of leg conduit arteries. In addition, the effectiveness of resistive vibration exercise as a countermeasure for vascular deconditioning during bed rest was evaluated. Sixteen healthy men were randomly assigned to bed rest (BR-Ctrl) or to bed rest with resistive vibration exercise (BR-RVE). Before and after 25 and 52 days of strict horizontal bed rest, arterial diameter, blood flow, flow-mediated dilatation (FMD), and nitroglycerin-mediated dilatation were measured by echo Doppler ultrasound. In the BR-Ctrl group, the diameter of the common femoral artery decreased by 13 +/- 3% after 25 and 17 +/- 1% after 52 days of bed rest (P < 0.001). In the BR-RVE group this decrease in diameter was significantly attenuated (5 +/- 2% after,25 days and 6 +/- 2% after 52 days, P < 0.01 vs. BR-Ctrl). Baseline blood flow did not change after bed rest in either group. After 52 days of bed rest, FMD and nitroglycerin-mediated dilatation of the superficial femoral artery were increased in both groups, possibly by increased nitric oxide sensitivity. In conclusion, bed rest deconditioning is accompanied by a reduction in the diameter of the conduit arteries and by an increased reactivity to nitric oxide. Resistive vibration exercise effectively attenuates the diameter decrease of leg conduit arteries after bed rest.