Resuscitation of a defective prophage in Salmonella cocultures
Resuscitation of a defective prophage in Salmonella cocultures
复制标题
DOI：
10.1128/jb.186.12.4038-4041.2004
复制
发表时间：
2004-06-01
影响因子：
3.2
通讯作者：
Bossi, L
中科院分区：
文献类型：
--
作者：
Figueroa-Bossi, N;Bossi, L
广泛研究的肠沙门氏菌鼠伤寒血清型菌株 ATCC 14028s 和 SL1344 含有一种神秘的 ST64B 原噬菌体，无法产生传染性病毒粒子。我们发现，将任一菌株与缺乏原噬菌体的同基因同胞共培养都会导致病毒活性形式的出现。活性噬菌体起源于假定尾部组装假基因中单调 G:C 运行中 +1 移码突变的回复。
Widely studied Salmonella enterica serovar Typhimurium strains ATCC 14028s and SL1344 harbor a cryptic ST64B prophage unable to produce infectious virions. We found that coculturing either strain with an isogenic sibling lacking the prophage leads to the appearance of active forms of the virus. Active phage originates from reversion of a +1 frameshift mutation at a monotonous G:C run in a presumptive tail assembly pseudogene.