Reciprocal changes in serum levels of immunoglobulins (IgG, IgA, IgM) and complements (C3, C4) in normal pregnancy and after delivery.
Reciprocal changes in serum levels of immunoglobulins (IgG, IgA, IgM) and complements (C3, C4) in normal pregnancy and after delivery.
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正常妊娠和分娩后血清中免疫球蛋白（IgG、IgA、IgM）和补体（C3、C4）水平的相互变化。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
N. Amino
中科院分区：
文献类型：
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作者：
M. Yasuhara;H. Tamaki;S. Iyama;Y. Yamaguchi;J. Tachi;N. Amino
本文对8例健康妇女血清IgG、伊加、IgM和补体C_3、C_4在妊娠期及妊娠后的动态变化进行了研究。血清IgG在妊娠期间逐渐下降，但在分娩后6个月内明显升高。血清伊加和IgM水平也显示出与IgG相似的模式。与此相反，C3和C4水平显着增加，并在怀孕的最后三个月达到最高水平，但分娩后6个月逐渐下降。免疫球蛋白和补体之间的相互变化首次得到澄清，并提示在妊娠期间抑制体液免疫系统的代偿性自身调节机制。
Sequential changes in serum levels of IgG, IgA, and IgM, and C3 and C4 during and after pregnancy were studied in 8 healthy women. Serum IgG decreased gradually during pregnancy, but increased markedly during the six months following delivery. Serum IgA and IgM levels also showed patterns similar to IgG. In contrast, C3 and C4 levels increased significantly and reached maximum levels in the last trimester during pregnancy, but decreased gradually for six months after delivery. Reciprocal changes between immunoglobulins and complements were clarified for the first time, and were suggestive of a compensatory autoregulatory mechanism in the suppression of the humoral immune system during pregnancy.