Distribution and abundance of microsatellites in the yeast genome can be explained by a balance between slippage events and point mutations
Distribution and abundance of microsatellites in the yeast genome can be explained by a balance between slippage events and point mutations
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DOI：
10.1093/oxfordjournals.molbev.a026404
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发表时间：
2000-08-01
影响因子：
10.7
通讯作者：
Aquadro, CF
中科院分区：
文献类型：
--
作者：
Kruglyak, S;Durrett, R;Aquadro, CF
我们适合Kruglyak等人介绍的微卫星进化的马尔可夫链模型。在酵母基因组中的所有二，三和四核苷酸重复的数据。我们的研究结果表明，微卫星的丰度和长度的分布的许多功能可以解释这个简单的模型，其中包括滑移事件和碱基对替换之间的竞争，没有必要调用选择或限制的长度。我们的研究结果提供了一些新的信息，个别重复基序的滑移率，这表明AT丰富的三核苷酸重复有较高的滑移率。正如我们的模型预测的那样，我们发现许多重复序列与相同基序的较短重复序列相邻。然而，我们也发现了一个显着的趋势，不同图案的微卫星集群。
We fit a Markov chain model of microsatellite evolution introduced by Kruglyak ct al. to data on all di-, tri-, and tetranucleotide repeats in the yeast genome. Our results suggest that many features of the distribution of abundance and length of microsatellites can be explained by this simple model, which incorporates a competition between slippage events and base pair substitutions, with no need to invoke selection or constraints on the lengths. Our results provide some new information on slippage rates for individual repeat motifs, which suggest that AT-rich trinucleotide repeats have higher slippage rates. As our model predicts, we found that many repeats were adjacent to shorter repeats of the same motif. However, we also found a significant tendency of microsatellites of different motifs to cluster.