Efficacy and cost-effectiveness of octenidine wound gel in the treatment of chronic venous leg ulcers in comparison to modern wound dressings
Efficacy and cost-effectiveness of octenidine wound gel in the treatment of chronic venous leg ulcers in comparison to modern wound dressings
复制标题
DOI：
10.1111/iwj.12250
复制
发表时间：
2016-04-01
影响因子：
3.1
通讯作者：
Strohal, Robert
中科院分区：
文献类型：
--
作者：
Haemmerle, Gilbert;Strohal, Robert
本研究的目的是确定以辛替尼定为基础的伤口凝胶治疗慢性静脉性小腿溃疡的有效性、安全性和成本效益。为此，49个创面接受了单独使用现代创面相适应敷料(治疗组1；n=17)、奥替尼定创面凝胶加现代创面相适应敷料(治疗组2；n=17)或仅使用奥替尼定创面凝胶(治疗组3；n=15)的治疗。在每隔3~5天更换一次敷料的42天研究期间，对不同敷料的创面愈合特点和治疗费用进行分析。与现代敷料相比，两个辛替尼丁创面凝胶治疗组的伤口缩小效果显著(P=0028)，治疗组1-3组的创面总缩小率分别为146%、641%和962%。仅在奥替尼定创面凝胶治疗(n=9)下观察到早期伤口愈合，因此仅使用奥替尼丁创面凝胶产生的治疗成本最低(Euro2034/换药)。因此，从安全和促进伤口愈合两方面考虑，辛替尼定创面凝胶性价比高，非常适合治疗慢性静脉性小腿溃疡。
The aim of this study was to determine the efficacy, safety and cost-effectiveness of an octenidine-based wound gel in the treatment of chronic venous leg ulcers. For this purpose, 49 wounds were treated with either modern wound-phase-adapted dressings alone (treatment arm 1; n=17), octenidine wound gel plus modern wound-phase-adapted dressings (treatment arm 2; n=17) or octenidine wound gel alone (treatment arm 3; n=15). During the study period of 42days with dressing changes every 3-5days, wound healing characteristics and treatment costs of different dressings were analysed. Wound size reduction was significantly better (P=0028) in both octenidine wound gel treatment arms compared to modern dressings alone with total reductions of 146%, 641% and 962% in treatment arms 1-3. Early wound healing was merely observed under octenidine wound gel treatment (n=9), whereby lowest treatment costs were generated by octenidine wound gel alone (Euro2034/dressing change). As a result, the octenidine wound gel is cost-effective and well suitable for the treatment of chronic venous leg ulcers, considering both safety and promotion of wound healing.