Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21
Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21
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DOI：
10.2119/molmed.2011.00075
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发表时间：
2011-07-01
影响因子：
5.7
通讯作者：
Papavassiliou, Athanasios G.
中科院分区：
文献类型：
--
作者：
Chartoumpekis, Dionysios V.;Habeos, Ioannis G.;Papavassiliou, Athanasios G.
成纤维细胞生长因子-21（FGF21）是一种多效性蛋白，参与葡萄糖、脂质代谢和能量稳态，主要表达组织是肝脏和脂肪组织。棕色脂肪组织（BAT）负责啮齿类动物冷诱导的生热作用。 FGF21 在 BAT 生物学中的作用尚未得到研究。在本研究中，使用野生型 C57BL/6J 小鼠以及棕色脂肪细胞系来探索冷暴露和 β3-肾上腺素能刺激对 BAT 中 FGF21 表达的潜在作用。我们的结果表明，短期暴露于寒冷以及 β3-肾上腺素能刺激会导致 BAT 中 FGF21 mRNA 水平的显着诱导，但不会伴随 FGF21 血浆水平的增加。这一发现为药物的潜在用途开辟了新途径，这些药物可以诱导 FGF21，从而激活 BAT 生热作用。 (C) 2011 年范斯坦医学研究所，www.feinsteininstitute.org
Fibroblast growth factor-21 (FGF21) is a pleiotropic protein involved in glucose, lipid metabolism and energy homeostasis, with main tissues of expression being the liver and adipose tissue. Brown adipose tissue (BAT) is responsible for cold-induced thermogenesis in rodents. The role of FGF21 in BAT biology has not been investigated. In the present study, wild-type C57BL/6J mice as well as a brown adipocyte cell line were used to explore the potential role of cold exposure and beta 3-adrenergic stimulation in the expression of FGF21 in BAT. Our results demonstrate that short-term exposure to cold, as well as beta 3-adrenergic stimulation, causes a significant induction of FGF21 mRNA levels in BAT, without a concomitant increase in FGF21 plasma levels. This finding opens new routes for the potential use of pharmaceuticals that could induce FGF21 and, hence, activate BAT thermogenesis. (C) 2011 The Feinstein Institute for Medical Research, www.feinsteininstitute.org