The effects of antigen on the migration of recirculating lymphocytes through single lymph nodes.
The effects of antigen on the migration of recirculating lymphocytes through single lymph nodes.
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DOI：
10.1084/jem.143.4.870
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发表时间：
1976-04-01
影响因子：
15.3
通讯作者：
Trnka, Z
中科院分区：
文献类型：
--
作者：
Cahill, R N;Frost, H;Trnka, Z
增加输入的RL到LN开始在3小时内抗原刺激后，是由于通过LN的RL的数量增加。它与大多数RL通过LN的通过时间改变无关，并且在没有高内皮PCV的情况下不会发生。RL从抗原刺激的LN中输出的立即减少是由于在给予抗原之前已经进入LN的RL从该LN中退出的延迟。抗原给药后LN细胞输出的减少影响LN内产生的母细胞以及小淋巴细胞，并且对RL没有特异性。至少有两种不同的机制控制RL通过抗原刺激的LN的迁移。第一个控制RL的增加输入，其仅通过高内皮PCV发生。第二个控制细胞输出的立即减少，虽然它不会发生在高内皮PCV水平，但只能发生在有组织的淋巴组织中。RL输入到抗原刺激的LN中的增加和LN的细胞输出的减少可以独立地发生，并且可能由不同的机制控制。
The increased input of RL into LN starts within 3 h after antigenic stimulation and is due to an increase in the number of RL passing through a LN. It is not associated with an altered transit time through a LN of the majority of RL and it cannot occur in the absence of high endothelial PCV. The immediate decrease in the output of RL from an antigen-stimulated LN is due to a delay in the exit from that LN of RL which had entered the LN before antigen was given. The decrease in cell output from a LN after antigen administration affects blast cells produced within the LN as well as small lymphocytes and is not specific for RL. There are at least two distinct mechanisms controlling the migration of RL through an antigen-stimulated LN. The first controls the increased input of RL which occurs only through high endothelial PCV. The second controls the immediate decrease in cell output, which although it does not occur at the level of the high endothelial PCV, can only occur in organized lymphoid tissue. The increased input of RL into an antigen-stimulated LN and the decreased cell output from the LN can occur independently and are possibly controlled by different mechanisms.