ANTIINFLAMMATORY EFFECT OF CURCUMA-XANTHORRHIZA ROXB AND ITS ACTIVE PRINCIPLES
ANTIINFLAMMATORY EFFECT OF CURCUMA-XANTHORRHIZA ROXB AND ITS ACTIVE PRINCIPLES
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DOI：
10.1248/cpb.38.1045
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发表时间：
1990-04-01
影响因子：
1.7
通讯作者：
OZAKI, Y
中科院分区：
文献类型：
--
作者：
OZAKI, Y
姜黄根茎ROXB。在印尼民间医药中用作催胆剂、芳香胃药、镇痛剂、风湿病药等。本研究旨在阐明从这些根茎中提取的甲醇提取物的抗炎作用及其作用原理。甲醇提取物在乙醚和水之间分离，然后用正己烷提取醚溶部分。正己烷可溶性部分（前1 - 4），前2部分（前5 - 6），后3部分（前8 - 10）用硅胶柱层析法进行再层析。研究其对角叉菜胶致大鼠水肿和醋酸致小鼠血管通透性及扭体症状的抗炎作用。甲醇提取物（p.o.）具有抗炎和镇痛活性，且这些活性依次转移到醚溶部分、正己烷溶部分、II、V和IX。经化学结构鉴定为德玛酮。这些结果表明，姜黄的抗炎作用是其所含的德国酮的结果。
The rhizomes of Curcuma xanthorrhiza ROXB. are used in Indonesian folk medicine as cholagogues, aromatic stomachics, analgesics, a rheumatic remedy, etc. The present study was carried out to elucidate the antiinflammatory effect of the methanol extract obtained from these rhizomes, and its active principles. The methanol extract was partitioned between ether and water, and then the ether-soluble fraction was extracted with n-hexane. The n-hexane-soluble fraction was chromatographed (fr. I-IV), fr. II was rechromatographed (fr. V-VI), and then fr. V was rechromatographed (fr. VIII-X) by silica gel column chromatography. The antiinflammatory activity of these fractions was investigated on carrageenin-induced edema in rats and acetic acid-induced vascular permeability as well as the writhing symptom in mice. The methanol extract (p.o.) showed both an antiinflammatory activity and an analgesic activity and these activities shifted successively to the ether-soluble fraction, the n-hexane-soluble fraction, fr. II, V and IX. Chemical structure of fr. IX was identified as germacrone. These results suggest that the antiinfalmmatory action of Curcuma xanthorrhiza is the result of the germacrone that it contains.