Effect of strenuous physical exercise on circulating cell-derived microparticles
Effect of strenuous physical exercise on circulating cell-derived microparticles
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DOI：
10.3233/ch-2010-1361
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发表时间：
2011-01-01
影响因子：
2.1
通讯作者：
Connes, Philippe
中科院分区：
文献类型：
--
作者：
Chaar, Vicky;Romana, Marc;Connes, Philippe
剧烈运动与涉及多种血细胞激活的炎症反应有关。为了记录这些细胞类型的特异性激活，我们研究了三种最大力竭运动测试对健康受试者循环细胞衍生微粒和炎症分子的定量和定性模式的影响。这项研究主要表明，剧烈运动后，血浆中血小板和多形核中性粒细胞（PMN）微粒的浓度立即升高。此外，在恢复2小时后，仍观察到来自PMN和血小板的微粒的血浆浓度增加。 IL-6 血浆水平也观察到类似的模式。相反，对于可溶性选择素或来自红细胞、单核细胞和内皮细胞的微粒的血浆浓度没有观察到变化。一致认为，sVCAM-1 和 sICAM-1 水平并未因练习而改变。我们得出的结论是，剧烈运动会伴随血小板和中性粒细胞衍生的微粒产生，这可能反映了这两种细胞类型的激活。
Strenuous exercise is associated with an inflammatory response involving the activation of several types of blood cells. In order to document the specific activation of these cell types, we studied the effect of three maximal exercise tests conducted to exhaustion on the quantitative and qualitative pattern of circulating cell-derived microparticles and inflammatory molecules in healthy subjects. This study mainly indicated that the plasma concentration of microparticles from platelets and polymorphonuclear neutrophils (PMN) was increased immediately after the strenuous exercise. In addition, the increase in plasma concentration of microparticles from PMN and platelets was still observed after 2 hours of recovery. A similar pattern was observed for the IL-6 plasma level. In contrast, no change was observed for either soluble selectins or plasma concentration of microparticles from red blood cells, monocytes and endothelial cells. In agreement, sVCAM-1 and sICAM-1 levels were not changed by the exercise. We conclude that a strenuous exercise is accompanied by platelet-and PMN-derived microparticle production that probably reflects the activation of these two cell types.