Phototherapy for Neonatal Jaundice-Therapeutic Effects on More Than One Level?
Phototherapy for Neonatal Jaundice-Therapeutic Effects on More Than One Level?
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DOI：
10.1053/j.sempen.2010.02.008
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发表时间：
2010-06-01
影响因子：
3.4
通讯作者：
Hansen, Thor Willy Ruud
中科院分区：
文献类型：
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作者：
Hansen, Thor Willy Ruud
黄疸的光疗是新生儿医学中常见的治疗方法，用于预防胆红素的神经毒性作用。研究评估了光疗光的最佳波长，辐照度和光谱功率的重要性，以及光源的类型，包括使用单个光源和多个光源。结果测量是需要光疗的持续时间或在给定时间内血清胆红素的降低率。近年来，核黄疸的明显复苏迫使我们把重点放在严重黄疸婴儿的紧急管理上。几项研究表明，快速降低血清总胆红素水平是可能的。从这个角度来看，光异构体形成的速度似乎很重要，理论上也可能具有神经保护作用，因为光异构体的极性更强。这项工作回顾了有关光异构体形成速度的证据，以及有关胆红素异构体相对神经毒性的证据。中国生物医学工程学报，34 (4):331 - 334 (C) 2010。版权所有。
Phototherapy for jaundice is a common treatment in neonatal medicine and is used to prevent the neurotoxic effects of bilirubin. Studies have assessed the optimal wavelength of phototherapy light, the importance of irradiance and spectral power, and the types of light source, including the use of single versus multiple light sources. Outcome measures have been duration of need for phototherapy or rate of reduction of serum bilirubin over a given time. An apparent resurgence of kernicterus in recent years has forced us to focus on the emergency management of severely jaundiced infants. Several studies have shown that very rapid reductions of total serum bilirubin levels are possible. The speed with which photoisomers are formed appears to be important both from this perspective and theoretically may also be neuroprotective because of the more polar nature of the photoisomers. This work reviews the evidence concerning the speed of photoisomer formation, as well as the evidence regarding the relative neurotoxicity of bilirubin isomers. Semin Perinatol 34:231-234 (C) 2010 Elsevier Inc. All rights reserved.