Anticentromere antibody. Clinical Correlations and association with favorable prognosis in patients with scleroderma variants.
Anticentromere antibody. Clinical Correlations and association with favorable prognosis in patients with scleroderma variants.
复制标题
抗着丝粒抗体。
作者：
G. Mccarty;J. Rice;M. Bembe;F. A. Barada
染色体着丝粒抗体的存在似乎与一部分患有有限CREST形式硬皮病的患者有关。为了进一步确定这种自身抗体的预后价值，27例患者，谁被确定为具有抗着丝粒抗体筛选抗核抗体试验使用HEp-2细胞底物，临床和血清学随访2年。抗着丝粒抗体的存在在有限的CREST形式的系统性硬化症中是常见的，并且它通常是CREST变体患者血清中存在的唯一自身抗体特异性。当与其他患者相比，谁表现出斑点或核仁抗核抗体模式，抗着丝粒抗体有显着较少的主要器官系统的参与。
The presence of antibody to the chromosomal centromere appears to be associated with a subset of patients with the limited CREST form of scleroderma. To further define the prognostic value of this autoantibody, 27 patients, who were identified as having anticentromere antibody by screening antinuclear antibody tests using HEp-2 cell substrates, were followed clinically and serologically for 2 years. The presence of anticentromere antibody is common in the limited CREST forms of systemic sclerosis, and it is often the only autoantibody specificity present in the sera of patients with the CREST variant. When compared with other patients who exhibit speckled or nucleolar antinuclear antibody patterns, those with anticentromere antibody had significantly less major organ system involvement.