Epidemiologic features of children with Epstein-Barr virus associated diseases in Hangzhou, China
Epidemiologic features of children with Epstein-Barr virus associated diseases in Hangzhou, China
复制标题
杭州市儿童EB病毒相关疾病流行病学特征
DOI：
10.1002/jmv.25633
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发表时间：
2019-12-19
影响因子：
12.7
通讯作者：
Li, Wei
中科院分区：
文献类型：
--
作者：
Shi, Jianrong;Ma, Wangqian;Li, Wei
eb病毒（EBV）感染是多种疾病的病原体。血液中EBV DNA是EBV感染和再激活的有用诊断标志物。本研究旨在了解中国东部杭州市EBV DNA阳性儿童EBV相关疾病的流行病学信息。纳入2010 - 2015年浙江大学医学院儿童医院收治的所有疑似EBV相关疾病患儿，并采用实时定量聚合酶链反应检测血清EBV DNA。10470例患儿中，EBV DNA阳性1205例，阳性率为11.5%。1 ~ 7岁患者中有15.8%（973 / 6162）由EBV引起，而7岁以上儿童中有6.6%（179 / 2708）由EBV引起（P < 0.01），婴儿中有3.3%（53 / 1600）由EBV引起
Epstein-Barr virus (EBV) infection is the causative agent of multiple diseases. EBV DNA in blood is a useful diagnostic marker of primary EBV infection and reactivation. This study aimed to provide epidemiological information on children with EBV-associated diseases identified by positive EBV DNA in Hangzhou, a city in East China. All children admitted to the Children's Hospital of Zhejiang University School of Medicine from 2010 to 2015 with suspected EBV-related diseases and serum EBV DNA tested by quantitative real-time polymerase chain reaction were included. Of the 10 470 children, 1205 were determined to have positive EBV DNA, and the positive rate was 11.5%. 15.8% (973 of 6162) of the illnesses of patients aged 1 to 7 years were caused by EBV as compared to that of 6.6% (179 of 2708) of children older than 7 years (P < .01) and 3.3% (53 of 1600) of of that of infants