Stage Migration in Clinically Localized Prostate Cancer
Stage Migration in Clinically Localized Prostate Cancer
复制标题
临床局限性前列腺癌的分期迁移
作者：
J. Noldus;M. Graefen;A. Haese*;R. Henke;P. Hammerer;H. Huland
目的：为了确定是否迁移的病理肿瘤阶段的患者与临床局限性前列腺癌的存在，这是否是由于增加频率的治疗患者与临床无关cancer.Methods：1,063根治性耻骨后切除术进行临床局限性前列腺癌患者在一个机构内7.5年（从1992年至1999年6月）。根据斯坦福大学方案对所有标本进行前瞻性处理。然后，这些进行了分析，关于病理肿瘤阶段和癌症volumes.Results的迁移：在观察期内，根治性耻骨后前列腺切除术的年增长率从69至224例增加了225%。作者注意到晚期肿瘤分期的下降（从65%到40%）和病理T2肿瘤的增加（从30%到55%）。过去5年中，小型癌症（<0.5 cm 3）的发病率稳定在2%至5%之间。结论：数据证实了美国大型中心观察到的趋势，即局部前列腺癌的检测和治疗不断增加，而无需对临床上无意义的癌症进行不必要的治疗。
Objectives: To determine whether migration of pathological tumor stages in patients with clinically localized prostate cancer exists and whether this is due to an increasing frequency of treating patients with clinically insignificant cancer.Methods: 1,063 radical retropubic prostatectomies were performed in patients with clinically localized prostate cancer in one institution within 7.5 years (from 1992 until June 1999). All specimens were prospectively processed according to the Stanford protocol. These were then analyzed regarding the migration of pathological tumor stages and cancer volumes.Results: Within the observation period, the annual rate of radical retropubic prostatectomies increased by 225% from 69 to 224 cases. The authors noted a decline of advanced tumor stages (from 65 to 40%) and an increase in pathological T2 tumors (from 30 to 55%). The rate of small cancers (<0.5 cm3) remained stable between 2 and 5% over the last 5 years.Conclusion: The data confirm trends which were observed in large US centers with increasing detection and treatment of localized prostate cancer without unnecessary treatment of clinically insignificant cancers.
DOI：
10.1001/jama.1993.03510070082041
发表时间：
1993-08
期刊：
JAMA
影响因子：
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作者：
J. E. Oesterling;S. Jacobsen;C. Chute;H. Guess;C. Girman;Laurei A. Panser;M. Lieber
通讯作者：
J. E. Oesterling;S. Jacobsen;C. Chute;H. Guess;C. Girman;Laurei A. Panser;M. Lieber