Iridium-catalyzed H/D exchange into organic compounds in water
Iridium-catalyzed H/D exchange into organic compounds in water
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DOI：
10.1021/ja017219d
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发表时间：
2002-03-13
影响因子：
15
通讯作者：
Bergman, RG
中科院分区：
文献类型：
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作者：
Klei, SR;Golden, JT;Bergman, RG
空气稳定的配合物Cp*(PMe3) ircl2在不添加酸或稳定剂的情况下有效地催化D2O中的氘交换成有机分子的活化和未活化的C - H键。选择性在许多情况下被观察到，与活化初级C−H键优先发生。一些新的化学计量转化涉及铱催化剂前体也提出，包括与伯醇的氧化-脱碳反应。
The air-stable complex Cp*(PMe3)IrCl2efficiently catalyzes the exchange of deuterium from D2O into both activated and unactivated C−H bonds of organic molecules without added acid or stabilizers. Selectivity is observed in many cases, with activation of primary C−H bonds occurring preferentially. A number of new stoichiometric transformations involving the iridiym catalyst precursor are also presented, including an ozidation−decarbonylation reaction with primary alcohols.