Facile Diastereoseparation of Glycosyl Sulfoxides by Chiral Stationary Phase
Facile Diastereoseparation of Glycosyl Sulfoxides by Chiral Stationary Phase
复制标题
通过手性固定相轻松非对映分离糖基亚砜
作者：
Taniguchi T.;Asahata M.;Nasu A.;Shichibu Y.;Konishi K.;Monde K.
硫手性不同的糖基亚砜的非对映异构体的分离一直很困难。本文提出了一种使用手性固定相进行非对映分离的快速且可扩展的方法。该方法的实用性在 20 分钟内 500 毫克规模的分离以及三糖亚砜非对映体的分离中得到了证明。Chirality 28:534–539, 2016。© 2016 Wiley periodicals, Inc.
Separation of the diastereomers of glycosyl sulfoxides differing in the sulfur chirality has been difficult. This article presents a fast and scalable method for their diastereoseparation using a chiral stationary phase. The usefulness of this method was demonstrated in a 500‐mg scale separation within 20 min, and in the separation of trisaccharyl sulfoxide diastereomers.Chirality 28:534–539, 2016. © 2016 Wiley Periodicals, Inc.