Predictability and hierarchy in Drosophila behavior
Predictability and hierarchy in Drosophila behavior
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DOI：
10.1073/pnas.1607601113
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发表时间：
2016-10-18
影响因子：
11.1
通讯作者：
Shaevitz, Joshua W.
中科院分区：
文献类型：
--
作者：
Berman, Gordon J.;Bialek, William;Shaevitz, Joshua W.
即使是最简单的动物也会表现出复杂的时间动态行为序列。在为这些动力学提出的组织原则中，突出的是层次结构的思想，其中动物的运动可以被理解为一组嵌套的子集群。虽然这种类型的组织在运动控制和神经回路方面具有潜在的优势，但证明动物整个行为库的测量在范围和时间复杂性方面受到限制。在这里，我们使用最近开发的无监督技术来发现和跟踪果蝇在浅竞技场中移动时所执行的所有刻板行为的发生。计算苍蝇的未来行为的最佳预测表示，我们表明，苍蝇的行为表现出多个时间尺度，并组织成一个层次结构，这是指示其底层的行为程序和不断变化的内部状态。
Even the simplest of animals exhibit behavioral sequences with complex temporal dynamics. Prominent among the proposed organizing principles for these dynamics has been the idea of a hierarchy, wherein the movements an animal makes can be understood as a set of nested subclusters. Although this type of organization holds potential advantages in terms of motion control and neural circuitry, measurements demonstrating this for an animal's entire behavioral repertoire have been limited in scope and temporal complexity. Here, we use a recently developed unsupervised technique to discover and track the occurrence of all stereotyped behaviors performed by fruit flies moving in a shallow arena. Calculating the optimally predictive representation of the fly's future behaviors, we show that fly behavior exhibits multiple time scales and is organized into a hierarchical structure that is indicative of its underlying behavioral programs and its changing internal states.