Steroid-free living-donor liver transplantation in adults.
Steroid-free living-donor liver transplantation in adults.
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DOI：
10.1097/01.tp.0000172187.28376.3b
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发表时间：
2005-09
期刊：
影响因子：
6.2
通讯作者：
S. Marubashi;K. Dono;K. Amano;N. Hama;K. Gotoh;Hidenori Takahashi;Kazuhiko Hashimoto;A. Miyamoto;Y. Takeda;H. Nagano;K. Umeshita;M. Monden
中科院分区：
文献类型：
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作者：
S. Marubashi;K. Dono;K. Amano;N. Hama;K. Gotoh;Hidenori Takahashi;Kazuhiko Hashimoto;A. Miyamoto;Y. Takeda;H. Nagano;K. Umeshita;M. Monden
为了研究避免类固醇在成人活体肝移植中的益处，我们比较了9名接受巴利昔单抗或达利珠单抗的受者和13名接受类固醇的历史患者的临床过程。两组的1年患者和移植物存活率以及急性细胞排斥反应的发生率相似。免疫抑制的副作用往往是更频繁的类固醇组。在移植后早期测量的丙型肝炎病毒（HCV）-RNA水平在无类固醇组中仍然受到抑制。避免类固醇是有益的受体，因为类固醇的副作用和HCV的复发都可以避免。
To examine the benefits of steroid avoidance in adult living donor liver transplantation, we compared the clinical courses of nine recipients receiving basiliximab or daclizumab and 13 historical patients who received steroids. The 1-year patient and graft survival and the incidence of acute cellular rejection were similar in both groups. The side effects of immunosuppression tended to be more frequent in the steroid group. Hepatitis C virus (HCV)-RNA levels measured early after transplantation remained suppressed in the steroid-free group. Steroid avoidance was beneficial in the recipients, as both steroid side effects and recurrence of HCV could be avoided.