GENDER DIFFERENCES AND AGING - EFFECTS ON THE HUMAN HEART
GENDER DIFFERENCES AND AGING - EFFECTS ON THE HUMAN HEART
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DOI：
10.1016/0735-1097(95)00282-8
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发表时间：
1995-10-01
影响因子：
24
通讯作者：
ANVERSA, P
中科院分区：
文献类型：
--
作者：
OLIVETTI, G;GIORDANO, G;ANVERSA, P
目标。这项研究调查了女性和男性心脏中随着年龄增长而发生的左、右室肌细胞大小和数量的变化。男女寿命的差异可能与女性心脏结构随着年龄的增长而得到更好的保存有关，在此基础上提出了衰老过程对两种性别心肌完整性影响不同的假说。应用形态计量学方法分析了53例女性和53例男性心脏心肌细胞数量和大小的变化。在酶分离的细胞中测定单核和双核心肌细胞随年龄的变化。检查年龄从17岁到95岁不等。女性心脏的心肌质量、单核和双核心肌细胞总数、细胞平均直径和体积均保持不变，而男性心脏每年丢失心肌近1g，这一现象与百万个细胞的损失相似。这种损害累及左、右侧心脏，在剩余的细胞中，左、右室心肌细胞体积分别以158µm(3)/年和167µm(3)/年的速度增大。衰老不会导致女性心肌细胞丢失和心肌细胞反应性肥大，这表明性别差异在衰老过程对心脏的不利影响中可能起着重要作用。
Objectives. This study investigated the changes in myocyte size and number in the left and right ventricles that occur with aging in the female and male heart.Background. Differences in life span between women and men may be related to a better preservation of myocardial structure in the female heart with aging, On this basis, the hypothesis was advanced that the aging process has a different impact on the integrity of the myocardium in the two genders.Methods. Morphometric methodologies were applied to analyze the changes in number and size of ventricular myocytes in the hearts of 53 women and 53 men. The changes in mononucleated and binucleated myocytes with age were determined in enzymatically dissociated cells. The age interval examined varied from 17 to 95 years.Results. Aging was associated with a preservation of ventricular myocardial mass, aggregate number of mononucleated and binucleated myocytes, average cell diameter and volume in the female heart, In contrast, nearly 1 g/year of myocardium was lost in the male heart, and this phenomenon accounted for the loss of similar to 64 million cells. This detrimental effect involved the left and right sides of the heart, In the remaining cells, myocyte cell volume increased at a rate of 158 mu m(3)/year in the left and 167 mu m(3)/year in the right ventricle.Conclusions. Aging does not lead to myocyte cell loss and myocyte cellular reactive hypertrophy in women, indicating that gender differences may play a significant role in the detrimental effects of the aging process on the heart.