Voucher reinforcement improves medication adherence in HIV-positive methadone patients: A randomized trial
Voucher reinforcement improves medication adherence in HIV-positive methadone patients: A randomized trial
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DOI：
10.1016/j.drugalcdep.2006.09.019
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发表时间：
2007-04-17
影响因子：
4.2
通讯作者：
Hall, Sharon
中科院分区：
文献类型：
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作者：
Sorensen, James L.;Haug, Nancy A.;Hall, Sharon
该临床试验评估了一项应急管理干预措施，旨在提高艾滋病毒阳性美沙酮维持患者的用药依从性。经过 4 周的基线观察阶段后，符合条件的参与者 (N=66) 被随机分配到：(a) 每隔一周进行药物辅导课程，以协助制定依从策略（比较组）或 (b) 药物辅导加上凭证强化，以便按时打开电子药物上限（凭证组）。使用电子测量的基线依从性（服用的剂量百分比/总可能剂量的百分比）为 51%，使用自我报告为 75%，使用药丸计数为 75%。干预为期 12 周，并进行 4 周随访。临床试验的主要结局结果表明干预期间的有效性，使用电子测量（78% 与 56%）、药片计数（86% 与 75%）和自我报告（87% 与 69%）的凭证组和对照组之间的平均依从性存在显着差异。优惠券停止后，各组之间的差异逐渐消失。应急管理显示出作为促进该人群抗逆转录病毒药物依从性的策略的前景。 (c) 2006 Elsevier Ireland Ltd. 保留所有权利。
This clinical trial evaluated a contingency management intervention designed to improve medication adherence among HIV-positive methadone maintenance patients. After a 4-week baseline observation phase, eligible participants (N=66) were randomly assigned to: (a) medication coaching sessions every other week to assist with adherence strategies (comparison group) or (b) medication coaching plus voucher reinforcement for opening electronic medication caps on time (voucher group). Baseline adherence (percent doses taken/percent total possible doses) was 51% using electronic measurement, 75% using self-report and 75% using pill count. The intervention was provided for 12 weeks, with a 4-week follow-up. The primary outcome results of the clinical trial indicated effectiveness during the intervention, with significant mean adherence differences between voucher and comparison groups using electronic measurement (78% versus 56%), pill count (86% versus 75%), and self-report (87% versus 69%). Differences between groups faded after vouchers were discontinued. Contingency management shows promise as a strategy to promote antiretroviral medication adherence in this population. (c) 2006 Elsevier Ireland Ltd. All rights reserved.