PROGRAMMED CELL-DEATH AND THE CONTROL OF CELL-SURVIVAL - LESSONS FROM THE NERVOUS-SYSTEM
PROGRAMMED CELL-DEATH AND THE CONTROL OF CELL-SURVIVAL - LESSONS FROM THE NERVOUS-SYSTEM
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DOI：
10.1126/science.8235590
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发表时间：
1993-10-29
期刊：
影响因子：
56.9
通讯作者：
JACOBSON, MD
中科院分区：
文献类型：
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作者：
RAFF, MC;BARRES, BA;JACOBSON, MD
在脊椎动物神经系统的发育过程中，多达50%或更多的许多类型的神经元通常在与靶细胞形成突触连接后不久就会死亡。这种大量的细胞死亡被认为反映了这些神经元无法获得足够数量的特定神经营养因子，这些因子由靶细胞产生，并且是神经元存活所需的。这种调节神经元数量的神经营养策略可能只是有助于调节许多其他脊椎动物细胞类型数量的一般机制的一个例子，这些细胞类型也需要来自其他细胞的信号才能生存。这些存活信号似乎通过抑制内在的细胞自杀程序起作用，该程序的蛋白质组分在大多数细胞类型中明显地组成型表达。
During the development of the vertebrate nervous system, up to 50 percent or more of many types of neurons normally die soon after they form synaptic connections with their target cells. This massive cell death is thought to reflect the failure of these neurons to obtain adequate amounts of specific neurotrophic factors that are produced by the target cells and that are required for the neurons to survive. This neurotrophic strategy for the regulation of neuronal numbers may be only one example of a general mechanism that helps to regulate the numbers of many other vertebrate cell types, which also require signals from other cells to survive. These survival signals seem to act by suppressing an intrinsic cell suicide program, the protein components of which are apparently expressed constitutively in most cell types.