MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment.
MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment.
复制标题
DOI：
10.1038/onc.2015.89
复制
发表时间：
2015-11-26
期刊：
影响因子：
8
通讯作者：
Peter ME
中科院分区：
文献类型：
--
作者：
Kohlhapp FJ;Mitra AK;Lengyel E;Peter ME
癌细胞生长在由多种成分组成的环境中，这些成分支持肿瘤生长并有助于治疗抗性。肿瘤微环境中的主要细胞类型是成纤维细胞、内皮细胞和浸润性免疫细胞，所有这些细胞都与癌细胞沟通。这些细胞类型促进癌症进展的一种方式是通过改变癌细胞或相关正常细胞中miRNA的表达，miRNA是负调节蛋白质表达的小的非编码RNA。miRNA表达的变化可以通过基质细胞和癌细胞之间的直接相互作用，通过任何细胞类型分泌的旁分泌因子，或甚至通过分泌的miRNA在细胞之间的直接通信来实现。如果我们要了解肿瘤进展并设计新的治疗方法，那么了解miRNA在肿瘤与其微环境中细胞之间复杂相互作用中的作用是必要的。
Cancer cells grow in an environment comprised of multiple components that support tumor growth and contribute to therapy resistance. Major cell types in the tumor micro-environment are fibroblasts, endothelial cells and infiltrating immune cells all of which communicate with cancer cells. One way that these cell types promote cancer progression is by altering expression of miRNAs, small noncoding RNAs that negatively regulate protein expression, either in the cancer cells or in associated normal cells. Changes in miRNA expression can be brought about by direct interaction between the stromal cells and cancer cells, by paracrine factors secreted by any of the cell types, or even through direct communication between cells through secreted miRNAs. Understanding the role of miRNAs in the complex interactions between the tumor and cells in its micro-environment is necessary if we are to understand tumor progression and devise new treatments.