Caspase-3 and caspase-6 in ductal breast carcinoma:: a descriptive study
Caspase-3 and caspase-6 in ductal breast carcinoma:: a descriptive study
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DOI：
10.14670/hh-21.1321
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发表时间：
2006-12-01
影响因子：
2
通讯作者：
Palacios, J.
中科院分区：
文献类型：
--
作者：
Blazquez, S.;Sirvent, J. J.;Palacios, J.
Caspase是凋亡过程中的主要环节。我们收集了210例乳腺导管癌（pT 1-pT 2）的肿瘤大小、组织分化程度、淋巴结状态和浸润性肿瘤坏死等信息，并通过TUNEL技术和免疫组化研究来评估凋亡细胞或凋亡小体的数量，以评估caspase 3和caspase 6的表达，我们的研究结果表明淋巴结状态和细胞增殖是复发和死亡的独立预后因素，只有肿瘤大小是复发的独立预后因素。然而，凋亡指数、半胱天冬酶免疫组化表达和细胞增殖指数均不是复发或复发的独立预后因素，这些结果表明，迄今为止已知的经典预后因素是预测疾病进展的最重要因素。
Caspases are the main point in the apoptotic process. We have collected some information from 210 cases of Ductal breast cancer (pT1-pT2) such as tumour size, histological differentiation degree, lymph node status and tumor necrosis in the infiltrating component and we have evaluated the number of apoptotic cells or bodies by TUNEL technique as well as immunohistochemical studies to evaluate the expression of caspase 3 and caspase 6, and proliferation index.Our results show that lymph node status and cell atypism are independent prognostic factors for recurrence and mortality and only tumour size is an independent prognostic factor for recurrence.However, the apoptotic index and the immunohistochemical expression of caspases and cell proliferation index have not turned out to be independent prognostic factors neither for recurrence nor mortality.These results show that classic prognostic factors known until now are the most important factors to predict the evolution of the illness.