DETECTION OF HIPPOCAMPAL PATHOLOGY IN INTRACTABLE PARTIAL EPILEPSY - INCREASED SENSITIVITY WITH QUANTITATIVE MAGNETIC-RESONANCE T(2) RELAXOMETRY
DETECTION OF HIPPOCAMPAL PATHOLOGY IN INTRACTABLE PARTIAL EPILEPSY - INCREASED SENSITIVITY WITH QUANTITATIVE MAGNETIC-RESONANCE T(2) RELAXOMETRY
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DOI：
10.1212/wnl.43.9.1793
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发表时间：
1993-09-01
期刊：
影响因子：
9.9
通讯作者：
GADIAN, DG
中科院分区：
文献类型：
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作者：
JACKSON, GD;CONNELLY, A;GADIAN, DG
海马体中异常的 T2 加权信号强度可能很难通过肉眼检测到，而 T2 映射提供了评估信号异常的客观方法。我们对 50 名患有顽固性部分性癫痫的成人门诊患者进行了调查，使用优化的 MRI 来检测海马和皮质灰质异常，并使用 MR T2 松弛映射。正常海马 T2 弛豫时间的范围很小（99 至 106 毫秒），并且观察者之间的测量结果是可重复的。 70% 的研究患者癫痫发作部位同侧海马 T2 弛豫时间异常，所有病例同侧海马异常更为严重。所有大于 116 毫秒的海马 T2 测量值均与颞叶癫痫和/或海马硬化的病理或 MRI 证据相关。 29% 的海马硬化病例存在双侧异常。
Abnormal T2-weighted signal intensity in the hippocampus may be difficult to detect visually, and T2 mapping provides an objective means of assessing signal abnormality. We investigated 50 adult outpatients suffering from intractable partial epilepsy with MRI optimized to detect hippocampal and cortical gray matter abnormalities, and with MR T2 relaxation mapping. The range of normal hippocampal T2 relaxation times is small (99 to 106 msec), and the measurements are reproducible between observers. There were abnormal hippocampal T2 relaxation times in the hippocampus ipsilateral to the site of seizure origin in 70% of patients studied, with the more severe abnormality in the ipsilateral hippocampus in all cases. All hippocampal T2 measurements greater than 116 msec were associated with temporal lobe epilepsy and pathologic or MRI evidence of hippocampal sclerosis, or both. Bilateral abnormalities were present in 29% of cases with hippocampal sclerosis.