A nitrous acid biosynthetic pathway for diazo group formation in bacteria
A nitrous acid biosynthetic pathway for diazo group formation in bacteria
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DOI：
10.1038/nchembio.1991
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发表时间：
2016-02-01
影响因子：
14.8
通讯作者：
Ohnishi, Yasuo
中科院分区：
文献类型：
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作者：
Sugai, Yoshinori;Katsuyama, Yohei;Ohnishi, Yasuo
虽然一些重氮化合物具有药用活性，但对自然界中重氮基团的形成知之甚少。在这里，我们描述了一个前所未有的亚硝酸生物合成途径，负责形成一个重氮基团的邻重氮醌的次级代谢产物cremeomycin在链霉菌cremeus的生物合成。这一发现不仅为重氮化合物的生物合成途径提供了重要的见解，也为其他含有氮-氮键的天然化合物提供了重要的见解。
Although some diazo compounds have bioactivities of medicinal interest, little is known about diazo group formation in nature. Here we describe an unprecedented nitrous acid biosynthetic pathway responsible for the formation of a diazo group in the biosynthesis of the ortho-diazoquinone secondary metabolite cremeomycin in Streptomyces cremeus. This finding provides important insights into the biosynthetic pathways not only for diazo compounds but also for other naturally occurring compounds containing nitrogen-nitrogen bonds.