DISCODERMOLIDE - A NEW BIOACTIVE POLYHYDROXYLATED LACTONE FROM THE MARINE SPONGE DISCODERMIA-DISSOLUTA
DISCODERMOLIDE - A NEW BIOACTIVE POLYHYDROXYLATED LACTONE FROM THE MARINE SPONGE DISCODERMIA-DISSOLUTA
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DOI：
10.1021/jo00303a029
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发表时间：
1990-08-03
影响因子：
3.6
通讯作者：
SCHULTE, GK
中科院分区：
文献类型：
--
作者：
GUNASEKERA, SP;GUNASEKERA, M;SCHULTE, GK
从加勒比海海绵中分离得到一种新的多羟基内酯，命名为discodermolide(1)，其结构经波谱技术，特别是核磁共振波谱确证，并经X-射线晶体分析确证。Discodermolide显示的碳骨架是新的；Discodermolide具有免疫抑制和细胞毒性。
A new polyhydroxylated lactone, discodermolide (1), was isolated from a Caribbean marine sponge, Discodermia dissoluta, and its structure was elucidated through a combination of spectroscopic techniques, in particular NMR spectroscopy, and verified by X-ray crystallographic analysis. The carbon skeleton displayed by discodermolide is new; discodermolide is immunosuppressive and cytotoxic.