Nitric oxide moves myoglobin centre stage
Nitric oxide moves myoglobin centre stage
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DOI：
10.1016/s0968-0004(01)01824-2
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发表时间：
2001-04-01
影响因子：
13.8
通讯作者：
Brunori, M
中科院分区：
文献类型：
--
作者：
Brunori, M
肌红蛋白（Mb）在心肌和骨骼肌中除了作为氧载体外，还具有一氧化氮（NO）清除剂的作用。一篇论文报告了从野生型或Mb敲除小鼠中分离的灌注心脏获得的数据，为Mb的这种新功能提供了第一个实验证据。本文概述了一氧化氮对心脏功能影响的生化基础，首先提出这种气体是细胞色素c氧化酶的抑制剂。这种新的Mb的作用和分子机制，以占氧合肌红蛋白与NO的高反应性的一些后果也进行了简要讨论。
It has been proposed that myoglobin (Mb), besides being an oxygen carrier, plays the role of a nitric oxide (NO) scavenger in heart and skeletal muscle. A paper reporting data obtained using perfused hearts isolated from either wild-type or Mb-knockout mice provides the first experimental evidence for this novel function of Mb. The biochemical basis underlying the effects of NO on cardiac function is outlined in this article, beginning with the idea that this gas is an inhibitor of cytochrome-c oxidase. Some of the consequences of this new role of Mb and a molecular mechanism to account for the high reactivity of oxymyoglobin with NO are also briefly discussed.