Disposition of all-trans-retinoic acid in mice following oral doses.
Disposition of all-trans-retinoic acid in mice following oral doses.
复制标题
口服剂量后小鼠体内全反式视黄酸的处置。
DOI：
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发表时间：
1981
影响因子：
3.9
通讯作者：
D. L. Hill
中科院分区：
文献类型：
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作者：
J. Kalin;M. E. Starling;D. L. Hill
口服 10 mg/kg 剂量后测量小鼠血清和组织中全反式视黄酸的浓度。药物的血清水平在 45 分钟内达到最大值，然后在 2 小时后以线性方式下降。组织水平在 30 至 120 分钟内达到最大值，然后在 3 小时后以指数方式下降，t 1/2 值为 25 至 68 分钟。在大脑中观察到最长的t 1/2 值。在胆汁和粪便中仅观察到少量未变化的全反式视黄酸，而在尿液中未发现。然而，极性物质存在于胆汁、粪便和尿液中。
The concentrations of all-trans-retinoic acid in serum and tissues from mice were measured following oral dosing with 10 mg/kg. Serum levels of the drug reached a maximum within 45 min, then declined after 2 hr in a linear fashion. Tissue levels reached a maximum within 30 to 120 min, then declined after 3 hr in an exponential fashion with t 1/2 values of 25 to 68 min. The longest t 1/2 value was observed in brain. Only small amounts of unchanged all-trans-retinoic acid were observed in bile and feces and none was found in urine. Polar material, however, was present in bile, feces, and urine.